|
KMID : 0984720070390040189
|
|
Infection and Chemotherapy
2007 Volume.39 No. 4 p.189 ~ p.195
|
|
|
Relationship between β-Lactam Antimicrobial Use and Antimicrobial resistance in Klebsiella pneumoniae Clinical Isolates at 5 Tertiary Hospitals in Korea
|
|
Jung Sook-In
Park Kyung-Hwa
Kwon Ki-Tae
Ko Kwan-Soo
Oh Won-Sup
Chung Doo-Ryeon
Peck Kyong-Ran
Yeom Joon-Sup
Chang Hyun-Ha
Kim Shin-Woo
Son Jun-Seong
Song Jae-Hoon
|
|
|
Abstract
|
|
|
Background : This study was performed to evaluate the prescribing pattern of β-lactam antibiotics and the relationship between antimicrobial resistance and antimicrobial use in 5 tertiary care hospitals in Korea. Materials and
Methods : Data on annual patient-days and annual consumption (defined daily dose (DDD) per 100 patient-days) of β-lactam antibiotics from 2003 to 2005 in 5 tertiary hospitals were analyzed. To determine the antimicrobial resistance in K. pneumoniae, broth microdilution test and double disk synergy were performed according to the CLSI performance standards. Spearman’s correlation coeffient was used to determine the relationship between antibiotic consumption and resistance.
Results : The prescription of β-lactam antibiotics in 5 tertiary hospitals markedly varied. In two hospitals, increase in consumption of β-lactam antibiotics was more than 30% during recent 3 years. The higher consumption of β-lactam antibiotics significantly correlated with the higher rate of antibiotic-resistant K. pneumoniae in 5 tertiary care hospitals.
Conclusion : Continuous surveillance of antibiotic use is needed to encourage appropriate prescribing of antibiotics and to reduce antibiotic resistance
|
|
|
KEYWORD
|
|
|
β-lactam antibiotics, Antibiotic use, Antibiotic resistance
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|